| ncRNA name | Smad1 siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human fetal RPE cells |
| Methods | fluorescein angiogram, immunohistochemistry, qRT-PCR, ELISA, Western blot, zymography, siRNA transfection |
| Expression pattern | associated |
| Functional description | Our studies identified an anti-angiogenic role for BMP4 in laser-induced CNV, mediated by direct inhibition of MMP-9 and indirect inhibition of VEGF. The inhibition of MMP-9 was Smad-dependent because BMP4 failed to repress TNF-induced MMP-9 expression when Smad1,5 was silenced by siRNA. |
| PubMed ID | 22392094 |
| Year | 2012 |
| Title | Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. |
| Drug-related ncRNA | NO |
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